“Mexico is one of the most important international market openings that Mannatech has ever undertaken, because Mexico is a hugely strategic market in its own right as well as a gateway to all Latin America,” said Randy Bancino, president of Mannatech’s international business. “Since 1994, our passion has been to support hard-working people looking to improve their lives through healthy living and building a business. We have found that the people of Mexico share our passion for changing people’s lives.”

Mannatech has distinguished itself in the emerging wellness and glyconutrient markets through the scientific development of its proprietary Ambrotose® complex. This technology holds more than 45 patents in 30 countries around the world. Many of Mannatech’s products, including Ambrotose, are based on Real Food TechnologySM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients.

“We have science as our foundation, and with a proven business model and products that will stand out in Mexico, I believe we will make a real difference in the lives of people willing to make a change,” said Sergio Medina, managing director of Mannatech’s Mexico operations. “There are more than 100 million people in Mexico, many of them looking to supplement their income and make a better quality of life for their families, and I believe Mannatech will help them discover that.”

According to the Direct Selling Association, Mexico is the sixth largest direct selling market in the world. Currently, more than two million people living in Mexico are involved with direct sales and are creating more than $3.5 billion in revenue.

Mannatech’s Mexico operations include offices and storefronts in both Guadalajara and Mexico City and a distribution center located in Monterrey. Individuals interested in Mannatech’s health and wellness products and business opportunity can learn more at mexicomannatech.com

“Sergio brings to Mannatech a wealth of global direct selling experience and local community ties, and we believe that establishing a presence in Mexico will provide us great opportunity for growth,” said Randy Bancino, president of Mannatech’s international business. “We are confident that our high quality, science-based wellness products and generous compensation plan will be extremely well received in Mexico, and Sergio Medina is the right executive to work with and support Associates and customers in Mexico and, ultimately, throughout Latin America.”

Medina brings more than 20 years of direct sales expertise, specifically in the health and wellness market based in Mexico. Most recently, he was managing director of ZRII since the beginning of its development across Mexico.

Prior to ZRII, Medina spent more than 17 years at Herbalife Mexico. As managing director/senior vice president of Mexico and Central America, he directed all operations, sales and marketing activities, helping the company grow from $6 million in annual revenue to more than $600 million when he left in 2007.

“There are more than 100 million people in Mexico, many of them looking to supplement their income and make a better quality of life for their families, and I believe Mannatech will help them discover that,” said Medina. “That number means opportunity for us, and we plan to show this wonderful country the real possibilities Mannatech has to offer, as well as the unique products that fit perfectly with this market, beginning just two months from now..”

According to the Direct Selling Association, Mexico is the sixth largest direct selling market in the world. Currently, more than two million people living in Mexico are involved in direct sales, and they have created more than $3.5 billion in revenue.

Mannatech kicks off its second Pre-Launch Road Show in Mexico this week with events in Guadalajara, Monterrey and Mexico City. Individuals interested in these events or in Mannatech’s products and business opportunity can learn more at mexicomannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit us.mannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

Media Contact:
Shawn Paul Wood
(972) 499-6614
Shawn.Wood@hck2.com

“The issuance of this new patent extends protection to our research and development of technology related to our PhytoMatrix caplets and PhytoBurst nutritional chews products and is an important addition to our current intellectual property portfolio,” said Robert A. Sinnott, Ph.D., MNS, co-CEO and chief science officer of Mannatech. “This is the first patent for technology related to these specific products and we will continue to protect this technology in other parts of the world.”

Mannatech currently holds 61 patents in 31 countries for its health-related technologies.

Many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit mannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

MEDIA CONTACT
Allison Lowe
(972) 499-6631
Allison.Lowe@hck2.com

(COPPELL) – The International Sport Karate Association (ISKA) recently selected Mannatech (NASDAQ: MTEX) as its exclusive dietary supplement provider. The announcement was made at ISKA’s 37^th annual U.S. Open, which featured more than 3,000 of the top martial artists from 40 participating countries and will be nationally televised on ESPN2 tomorrow, July 23, at 9 p.m. ET/6 p.m. PT.

“For the first time in the 25-year history of ISKA, we are happy to announce our partnership with Mannatech and share it with our more than 28,000 studio owners,” said Cory Schafer, president of ISKA.

“Third party certification by reputable organizations means Mannatech products have achieved a very rare level of purity, safety and trust,” said Robert A. Sinnott, Ph.D., MNS, co-CEO and chief science officer of Mannatech. “Many of our products are already certified Kosher and certified for GMP compliance by NSF International, but we believe having products certified by the ISKA governing body confirms the benefits our supplements have for elite athletes and others who are very particular about what they put into their bodies.”

The partnership will allow various Mannatech products to carry the ‘ISKA Certified for Elite Athletes’ seal, as well as a proven business-building opportunity for all studio owners represented by ISKA.

Present at the U.S. Open in Orlando were elite martial arts practitioners and Team Mannatech^SM athletes Chip Townsend and Ben Parra[1] who each set world records.

“Because of the variety of products offered in stores today, students often get confused with what nutritional supplements to take,” said Townsend. “This partnership will take the guesswork out of the purchase because Mannatech products are developed with real food technology solutions and without any banned substances.”

Replay dates of the ISKA U.S. Open will air on ESPN2, August 19 and 22 at 9 p.m. ET/6 p.m. PT.

For more information about ISKA, visit www.ISKA.com. For more information about the partnership, Mannatech’s products or business opportunity, visit www.Mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.Mannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.

###

Drs. Talitha Best and Eva Kemps of Flinders University in Adelaide, Australia, and Dr. Janet Bryan of the University of South Australia in Adelaide, Australia, published their findings of the 12-week study in the January 2010 issue of Developmental Neuropsychology, a peer-reviewed scientific journal.

“This rigorous double-blind, placebo-controlled study confirms important biological effects of Mannatech’s flagship and proprietary product, Ambrotose complex,” said Dr. Robert A. Sinnott, MNS, PhD, co-chief executive officer and chief science officer of Mannatech. “The significantly better performance on memory tasks and positive effects on mood experienced by the study participants who consumed Ambrotose complex is congruent with beneficial effects on brain functions.”*

The abstract of the study states that: “Before and after this supplementation period, participants completed alternate forms of standardized tests of cognition and self-report measures of well-being. Significant beneficial and longer-term effects of saccharide supplementation were found for memory performance and indicators of well-being. The potential for these nutrients to optimize cognitive function and well-being in older adults warrants on-going investigation.”² *

“Right now, commercial development of compounds to enhance cognitive functioning is one of the hottest areas of biomedical research,” Sinnott continued. “While most research focuses around synthetic compounds, Mannatech’s Ambrotose complex is comprised of ingredients that are isolated and purified from renewable natural sources, primarily plants. Mannatech has pioneered the field of nutritional glycobiology since 1996, and we will continue to be a leader in the future.”

Mannatech currently holds more than 45 patents in 30 countries for the technology related to Ambrotose complex.

In addition, many of Mannatech’s products are based on Real Food TechnologySM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients at nutritionally effective levels. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body. Mannatech offers the best alternative to synthetic vitamin and mineral products and so-called “super-juice” products.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at New.Mannatech.com.

¹ Mannatech, Incorporated donated the Ambrotose complex and placebo.

² Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Developmental Neuropsychology 2010; 35(1): 66 -80.

(COPPELL, Texas) April 20, 2010 - Mannatech, Incorporated (NASDAQ: MTEX – News), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of an independent study that demonstrated its proprietary Ambrotose^® complex and Advanced Ambrotose^® powder exerted prebiotic effects.* † The study was conducted by scientists at Ghent University and ProDigest, a leading company in gastrointestinal (GI) research.

The study, conducted at a top European research institute in Belgium, investigated the effects of Ambrotose complex and Advanced Ambrotose powder on the structure, composition and metabolism of the human GI tract using state-of-the-art human GI tract simulations and sophisticated microbiological analyses.

Its findings determined both Ambrotose complex and Advanced Ambrotose powder exhibited good selective fermentability throughout the entire colon, positive and selective bifidogenic effects and also demonstrated the possibility of enhancing species belonging to Bacteroidetes.

“We have been interested in the effects of Ambrotose products on GI health-a very hot area of scientific research-for many years,” said Mannatech’s Co-CEO and Chief Science Officer, Robert A. Sinnott, MNS, Ph.D. “A preliminary study published in 2007 showed that these products function as prebiotics, but the human gut is incredibly complex and difficult to study. To learn more, we chose to rely on the expertise of researchers on the forefront of human GI research. The work done by Dr. Marzorati and his team suggests that Ambrotose products support GI health throughout the entire colon; most prebiotics are thought to only exert such effects in the first portion of the colon.”

The study’s findings were published in the peer‐reviewed International Journal of Food Microbiology and indexed on PubMed by Drs. Massimo Marzorati and Sam Possemiers (U. of Ghent and ProDigest), A. Verhelst (ProDigest), Profs. Willy Verstraete and T. Van de Wiele (U. of Ghent) and Drs. Robert Sinnott and Gabriela Luta (Mannatech, Incorporated).[1]

“We are intensely interested in employing state-of-the-art technology to explore the effects of our Ambrotose products,” said Sinnott. “This study provides important information about the activities of these products in the human GI tract.”

Currently, Mannatech holds more than 45 patents in 30 countries for the technology related to Ambrotose complex.

In addition, many of Mannatech’s products are based on Real Food Technology^SM solutions, which provide consumers with products that contain standardized levels of natural and plant-sourced nutrients. Food-sourced ingredients are chosen from those scientifically proven to most benefit the human body. Mannatech offers the best alternative to synthetic vitamin and mineral products and so-called “super-juice” products.

For technical information about Mannatech’s products and scientific research publications, visit www.MannatechScience.org. Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at www.Mannatech.com.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and skin care products that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit www.AllAboutMannatech.com.

† Mannatech, Incorporated funded this study and donated the Ambrotose products used in this study.

[1] Marzorati M, Verhelst A, Luta G et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;doi: 10.1016/j.ijfoodmicro.2010.02.030.

(COPPELL, Texas) May 5, 2010 – Mannatech, Incorporated (NASDAQ: MTEX – News), a global pioneer in the development of high-quality health, weight and fitness and skin care solutions based on nutritional science, today announced its plans to launch business operations in Mexico on Jan. 24, 2011.

“Only Mannatech offers the dynamic combination of real scientifically validated products along with an award-winning compensation plan, and we are excited to partner with our independent sales Associates to bring the Mannatech opportunity to Mexico,” said Randy Bancino, president of Mannatech’s global business operations and expansion. “Our decision to enter Mexico is a strategic move and serves as a gateway to the Latin American market.”

According to the Direct Selling Association, Mexico – and its population of 110 million people – is the sixth-largest direct selling market in the world. Currently, more than two million people living in Mexico are involved with direct sales creating more than $3.5 billion in revenue.

“Since our founding in 1994, our philosophy has been to support people looking to change their lives through a personal commitment to healthy living and dedication to building a business. It will be an honor to offer these opportunities to the great country of Mexico,” said Robert A. Sinnott, MNS, Ph.D., co-CEO and chief science officer of Mannatech. “With more than 45 patents in 30 countries for the technology related to Ambrotose^® complex and an ongoing commitment to conduct clinical studies that demonstrate the efficacy of our products, validated science is at the core of who we are and what we do.”

Since 2007, Mannatech has invested approximately $15.7 million in world-class research and development efforts. Mannatech pioneered the concept of Real Food Technology^SM solutions by combining cutting-edge science with food-sourced ingredients to create the most nutritionally beneficial products for the human body.

“Mannatech offers real nutritional solutions to a Mexican market that is demanding substance over ‘hype’ and a real opportunity that can transcend the borders through our global seamless compensation plan,” said Al Bala, Mannatech’s senior vice president of global sales. “I am truly excited about our commitment to offer both short-term and long-term earning potential to a highly entrepreneurial culture.”

Mannatech will also host a Cinco de Mayo event at its headquarters in Coppell on Wednesday, May 5, at 6 p.m. CDT, to celebrate the announcement of the Mexico launch plans. The event is open to Associates and a guest and will be broadcast on www.mannatechlive.com/. This is a great opportunity for Mannatech’s Associates around the world to hear the vision, participate in a bilingual opportunity meeting and be one of the first to see the new Mannatech Mexico website.

For more information on Mannatech’s expansion plans into Mexico visit www.MexicoMannatech.com.

Individuals interested in Mannatech’s products or in exploring its business opportunity can learn more at mannatech.com.

About Mannatech

Mannatech, Incorporated develops high-quality health, weight and fitness, and skin care solutions that are based on the solid foundation of nutritional science and development standards. These proprietary products are available through independent sales Associates around the globe including the United States, Canada, South Africa, Australia, New Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the United Kingdom, Japan, Taiwan, Singapore and the Republic of Korea. For more information, visit AllAboutMannatech.com.

Please Note: This release contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of 1995. These forward-looking statements generally can be identified by use of phrases or terminology such as “intend” or other similar words or the negative of such terminology. Similarly, descriptions of Mannatech’s objectives, strategies, plans, goals or targets contained herein are also considered forward-looking statements. Mannatech believes this release should be read in conjunction with all of its filings with the United States Securities and Exchange Commission and cautions its readers that these forward-looking statements are subject to certain events, risks, uncertainties, and other factors. Some of these factors include, among others, Mannatech’s inability to attract and retain associates and members, increases in competition, litigation, regulatory changes, and its planned growth into new international markets. Although Mannatech believes that the expectations, statements, and assumptions reflected in these forward-looking statements are reasonable, it cautions readers to always consider all of the risk factors and any other cautionary statements carefully in evaluating each forward-looking statement in this release, as well as those set forth in its latest Annual Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed with the United States Securities and Exchange Commission, including its current reports on Form 8-K. All of the forward-looking statements contained herein speak only as of the date of this release.